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SKTN REACTIONS TO 9‐BROMOFLUORENE
Author(s) -
POWELL E. W.
Publication year - 1968
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1968.tb12335.x
Subject(s) - dermis , skin reaction , dermatology , medicine , contact dermatitis , hyperplasia , pathology , patch test , patch testing , epidermis (zoology) , anatomy , immunology , allergy
SUMMARY. A man aged 22, exposed to 9‐bromofluorene developed an extensive bullous eruption. A patch test with pure 9‐bromofluorene in a healthy subject not previously exposed to this substance provoked a mild and transient reaction at 24 hr., but a severe reaction 9–10 days later. The delayed reaction was characterized histologically by intense epidermal hyperplasia, pseudoepitheliomatous in degree, and a dense cellular infiltrate in the upper dermis. These effects are discussed in relation to the reactions normally obtained in contact hypersensitivity.