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LUPUS MURINUS
Author(s) -
MAGUIRE ANNE
Publication year - 1968
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1968.tb11976.x
Subject(s) - vaccination , lesion , lupus vulgaris , medicine , tuberculosis , systemic lupus erythematosus , vole , mycobacterium tuberculosis , pathology , dermatology , disease , population , environmental health
SUMMARY.— The history of the vole type of tubercle bacillus and of the Medical Research Council's trial of vole bacillus vaccine in 1950 is summarized. Fifteen years after this trial 110 vaccinated subjects were re‐examined. Seventeen were found to have granulomatous lesions at the vaccination site. The clinical and histological features of the lesions are described. No bacteria could be demonstrated in the lesions histologically or by inoculation of voles. The lesions responded to the administration of antituberculous drugs. The term lupus murinus is proposed for the dermatological lesion induced by primary inoculation with live Mycobacterium tuberculosis var . muris.