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THE ASSESSMENT OF FOUR NEW FLUOCORTOLONE ANALOGUES BY A MODIFIED VASOCONSTRICTION ASSAY
Author(s) -
BAKER HARVEY,
SATTAR H. A.
Publication year - 1968
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1968.tb11905.x
Subject(s) - library science , vasoconstriction , medicine , classics , history , computer science
SUMMARY. Four new derivatives of corticosterone, difluocortolone trime‐thylacetate, diffuocortolone alcohol, chlorcortolone alcohol and desfluochlorcortolone trimethylacetate have been compared with triamcinolone acetonide in a modified vasoconstriction assay. In a blind and randomized study using 35 healthy volunteer subjects it was demonstrated that 3‐fold increments of concentration could be differentiated and 6 coded concentrations of the test steroids were correctly put in rank order. A statistical analysis of the results showed that, in terms of median effective dosage (E.D.50) all of the test substances except desfluochlorcortolone trimethylacetate were significantly superior to triamcinolone acetonide in the context of this assay. There was no significant difference between the chlorcortolone and difluocortolone alcohols, which both showed a 5‐fold superiority in potency ratio over the reference steroid, Difluocortolone trimethylacetate appeared to have a potency ratio at least 10 times greater than triamcinolone acetonide. The continued investigation of these substances with a view to clinical trial would seem to be justified.