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LYMPHOCYTE TRANSFORMATION FOLLOWING B.C.G. VACCINATION
Author(s) -
SARKANY I.,
HALES HEATHER
Publication year - 1968
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1968.tb11902.x
Subject(s) - vaccination , medicine , dermatology , family medicine , library science , history , immunology , computer science
SUMMARY. The time‐course of lymphocyte transformation following B.C.G. vaccination was studied in 12 Mantoux negative nurses over a period of 7 weeks and in 5 subjects with a positive lymphocyte transformation test at the time of B.C.G. vaccination, when the Mantoux test was negative. Evidence of lymphocyte transformation was noted as early as the 13th day but was most commonly seen between the 16th and 23rd day after inoculation. Quantitative findings showed that there was an early peak in the lymphocyte response followed by a drop and a second peak at about 6 weeks. The correlation between the onset of lymphocyte transformation and Mantoux conversion was investigated in several cases. In no case was Mantoux testing superior in accuracy to the lymphocyte transformation test and a positive Mantoux reaction never preceded the appearance of blast‐like changes of lymphocytes in vitro. This method should be of practical value in those cases where a positive Mantoux reaction was expected and a negative intradermal test was obtained.