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THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE.
Author(s) -
PORTNOY BENJAMIN
Publication year - 1965
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1965.tb14579.x
Subject(s) - fluocinolone acetonide , citation , medicine , dermatology , library science , computer science
IN selecting the best bases for topical application of drugs, Williams (1964) has stressed the need for " much clinical study by many investigators over many years ". Penetration, defined by Goldsmith and Hellier (1954) as entry of a drug into the skin from a topically applied medicament, is likely to be different in normal and diseased skins. Kalz and Scott (1956) studied the therapeutic action of hydrocortisone in a variety of bases. They came to the conclusion that the differences they observed were not determined primarily by any specific infiuence of the bases on penetration, but rather depended on the compatibility of the base with the skin disease and its particular location. Jarrett (1961) has suggested that each type of skin disorder probably alters penetration in a different manner thus making a particular medicament from a particular vehicle more or less available to epidermal cells.