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Current progress in pharmacogenetics
Author(s) -
Blakey John D.,
Hall Ian P.
Publication year - 2011
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2011.03912.x
Subject(s) - pharmacogenetics , drug response , variation (astronomy) , genetic variation , computational biology , medicine , biology , drug , pharmacology , genotype , genetics , physics , gene , astrophysics
The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter‐individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.