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Case discussion of an immediate serious reaction to hexavalent vaccine mistaken for anaphylaxis
Author(s) -
Zai Giovanna,
Gottin Leonardo,
Boner Attilio,
Piacentini Giorgio,
Peroni Diego,
Gold Michael
Publication year - 2010
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2010.03771.x
Subject(s) - medicine , anaphylaxis , pediatrics , vaccination , vaccination schedule , tetanus , stridor , diphtheria , rash , adverse effect , dermatology , intensive care medicine , immunization , immunology , anesthesia , allergy , airway , antigen
Anaphylaxis is rarely associated with vaccination. Clinicalpresentation may include a variety of non-specic symptoms, making a clinical diagnosis uncertain. Therefore, it isimportant to distinguish anaphylaxis from other adverseevents following immunization (AEFIs), particularly in children, to manage subsequent immunizations where necessary. For administration of additional doses a specialistevaluation is recommended to conrm the diagnosis andconsider if re-vaccination is appropriate. A post-eventevaluation is based on an in-depth history and skin and invitro testing to identify specic sensitizations. Applying astandardized AEFI case denition, such as the Brighton Collaboration, is also helpful for individual cases as well aspharmacovigilance activitie