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Ischaemic complications of Glypressin in liver disease: a case series
Author(s) -
Donnellan Fergal,
Cullen Garret,
Hegarty John E.,
McCormick P. Aiden
Publication year - 2007
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2007.02921.x
Subject(s) - medicine , terlipressin , necrosis , incidence (geometry) , cirrhosis , fatty liver , surgery , chronic liver disease , disease , liver disease , gastroenterology , hepatorenal syndrome , physics , optics
Aim To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin). Methods We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so. Results Two patients were obese and developed extensive abdominal wall skin necrosis. The third patient had lower limb chronic venous insufficency and developed extensive necrosis of both lower limbs. Conclusions With increasing clinical use of terlipressin and an increasing incidence of obesity and non‐alcoholic fatty liver disease‐related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome.