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Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P‐glycoprotein
Author(s) -
Shimizu Mikiko,
Uno Tsukasa,
Sugawara Kazunobu,
Tateishi Tomonori
Publication year - 2006
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2006.02689.x
Subject(s) - fexofenadine , itraconazole , pharmacokinetics , crossover study , pharmacology , terfenadine , medicine , pharmacokinetic interaction , drug interaction , antifungal , dermatology , placebo , alternative medicine , pathology
Aims We determined whether or not the extent of drug interaction of fexofenadine by itraconazole is time‐dependent. Methods In a randomized two‐phase crossover study, itraconazole was administered orally for 6 days, and, on days 1, 3 and 6, fexofenadine was administered simultaneously. On another occasion, fexofenadine was administered alone. Results Itraconazole increased fexofenadine AUC(0, ∞), and the % change for difference was 178% (95% CI 1235, 3379), 205% (95% CI 1539, 3319) and 169% (95% CI 1128, 2987) on days 1, 3 and 6 of the 6 day treatment, respectively. Conclusions The extent of drug interaction by itraconazole was not time‐dependent.