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Herbal product–drug interactions mediated by induction
Author(s) -
Tirona Rommel G.,
Bailey David G.
Publication year - 2006
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2006.02684.x
Subject(s) - pharmacology , drug , medicine , drug interaction , medical prescription , phytotherapy , herb , traditional medicine , medicinal herbs , alternative medicine , pathology
Despite their common use, it is not widely recognized that herbal medicines can alter the efficacy of coadministered prescription drugs. Constituents in herbs interact with nuclear receptors to enhance metabolizing enzyme and/or transporter activity leading to reduced drug concentrations. Although St John’s wort was the first and most frequently reported source of induction‐style herb–drug interactions, this knowledge has not yet changed its current availability. This type of interaction is likely to be relevant to other herbal products. Caregivers need to be aware of the issues and options for therapeutic management.