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The role of pharmacogenetics in cancer therapeutics
Author(s) -
Yong Wei Peng,
Innocenti Federico,
Ratain Mark J.
Publication year - 2006
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2006.02591.x
Subject(s) - pharmacogenetics , medicine , drug response , drug , identification (biology) , cancer , precision medicine , bioinformatics , pharmacology , computational biology , genotype , biology , genetics , gene , pathology , botany
The variability in treatment responses and narrow therapeutic index of anticancer drugs are some of the key challenges oncologists face. The knowledge of pharmacogenetics can potentially aid in the discovery, development and ultimately individualization of anticancer drugs. The identification of genetic variations that predict for drug response is the first step towards the translation of pharmacogenetics into clinical practice. This review provides an update on the results of studies assessing the effects of germline polymorphisms and somatic mutations on therapeutic outcomes and highlights the potential applications and future challenges in pharmacogenetic research pertaining to cancer therapeutics.