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Absence of an interaction between iron and mycophenolate mofetil absorption
Author(s) -
Ducray Patricia Sanwald,
Banken Ludger,
Gerber Marianne,
Boutouyrie Bruno,
Zandt Hagen
Publication year - 2006
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02541.x
Subject(s) - mycophenolate , mycophenolic acid , bioavailability , medicine , crossover study , pharmacokinetics , pharmacology , confidence interval , concomitant , gastroenterology , transplantation , placebo , alternative medicine , pathology
Aim To determine whether concomitant iron affects the absorption of mycophenolate mofetil. Methods An open‐label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co‐administered with iron (treatment B). Results The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 ± 10.5 and 44.7 ± 12.4 µg ml −1 h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). Conclusions There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.