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µ‐Opiate receptor agonists – a new pharmacological approach to prevent motion sickness?
Author(s) -
Otto Bärbel,
Riepl Rudolf L.,
Otto Carsten,
Klose Joachim,
Enck Paul,
Klosterhalfen Sibylle
Publication year - 2006
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02505.x
Subject(s) - motion sickness , opiate , pharmacology , medicine , receptor , psychiatry
Aims Stress hormones might be involved in motion sickness. The influence of loperamide on kinetosis‐induced nausea and stress hormone release was investigated in a placebo‐controlled, cross‐over study. Methods Standardized rotation around the vertical axis combined with head movements was used to induce nausea 3 h after 16 mg loperamide or placebo ( n = 8). Plasma antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH) and nausea ratings were investigated. Results After loperamide nausea was significantly lower ( P < 0.02). ACTH ( P < 0.05) and ADH levels ( P < 0.02) increased significantly in both settings, but were lower after loperamide. Conclusions The susceptibility to develop kinetosis‐induced nausea and stress hormone release is decreased by loperamide, although the site of action remains speculative.