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Assessment of different methods of inhalation from salbutamol metered dose inhalers by urinary drug excretion and methacholine challenge
Author(s) -
Tomlinson Heather S.,
Corlett Sarah A.,
Allen Martin B.,
Chrystyn Henry
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02499.x
Subject(s) - salbutamol , methacholine , inhalation , medicine , pharmacology , excretion , drug , urinary system , anesthesia , asthma , respiratory disease , lung
Aims Methods to determine the lung delivery of inhaled bronchodilators from metered dose inhalers include urinary drug excretion 30 min post inhalation and methacholine challenge (P D 20 ). We have compared these two methods to differentiate lung delivery of salbutamol from metered dose inhalers using different inhalation methods. Methods In phase 1 of the study, on randomized study days, 12 mild asthmatics inhaled placebo, one and two 100 µg salbutamol doses from a breath actuated metered dose inhaler, in randomized fashion on different days. In phase 2, they inhaled one 100 µg salbutamol dose from a metered dose inhaler using a SLOW (20 l min −1 ) and a FAST (60 l min −1 ) inhalation technique and a slow inhalation delayed until after they had inhaled for 5 s (LATE). Urinary excretion of salbutamol (0–30 min) and P D 20 were measured after each dose. Results Following placebo, one and two 100 µg salbutamol doses, the geometric mean for P D 20 was 0.10, 0.41 and 0.86 mg respectively and the mean (SD) urinary drug excretion after one and two doses was 2.25 (0.65) and 5.37 (1.36) µg, respectively. After SLOW, FAST and LATE inhalations the geometric mean for P D 20 was 0.50, 0.40 and 0.42 mg, respectively, and mean (SD) salbutamol excretion was 2.67 (0.84), 1.90 (0.70) and 2.72 (0.67) µg, respectively. Only the amount of drug excreted during the FAST compared with the SLOW and LATE inhalations showed a statistical difference (95% confidence interval on the difference 0.12, 1.54 and 0.06,1.59 µg, respectively). Conclusions Urinary salbutamol excretion but not P D 20 showed differences between the inhalation methods used. When using a metered dose inhaler slow inhalation is better and co‐ordination is not essential if the patient is inhaling when they actuate a dose of the drug.