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Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese
Author(s) -
Luo ChenHui,
Wang An,
Zhu RongHua,
Zhang WeiXia,
Mo Wei,
Yu BangNing,
Chen GuoLin,
OuYang DongSheng,
Duan XiaoHong,
ElAty A. M. Abd,
Zhou HongHao
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02498.x
Subject(s) - cyp2c9 , medicine , chinese population , population , allele , allele frequency , gastroenterology , biology , genotype , genetics , metabolism , environmental health , cytochrome p450 , gene
Aims To investigate the association of CYP2C9 * 3 and * 6 with hyperlipidaemia in Chinese. Methods Four hundred and seventy‐six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR‐RFLP was used to identify CYP2C9 * 3 and * 6 . Results CYP2C9 * 6 was not detected in this study. The allelic frequency of CYP2C9 * 3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9 * 3 frequencies between males and females ( P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls ( P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9 * 3 frequency in patients with hyperlipidaemia was significantly lower than that in controls ( P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476). Conclusions The association of CYP2C9 * 3 with hyperlipidaemia was specific for females in this Chinese population.