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Mirtazapine‐induced arthralgia
Author(s) -
Passier Anneke,
Van Puijenbroek Eugène
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02481.x
Subject(s) - mirtazapine , pharmacovigilance , mianserin , medicine , nefazodone , pharmacology , onset of action , adverse effect , psychiatry , antidepressant , serotonin , anxiety , receptor , fluoxetine
Aim With this article, we intend to corroborate the assumed association between mirtazapine and arthralgia by presentation of eight case reports, and we describe a possible mechanism of action. Methods and results The Netherlands Pharmacovigilance Centre Lareb received eight case reports on arthralgia associated with use of mirtazapine. These case reports are presented in short. We also present worldwide data on this association. Conclusions The Lareb reports support the association between mirtazapine and arthralgia. A comparison is made between mirtazapine, mianserin and nefazodone, as these antidepressants show similarities in their mode of action and are all associated with arthralgia. We suggest that this adverse drug reaction may be induced by enhanced 5HT1‐mediated neurotransmission.