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No positive association between adrenergic receptor variants of α 2c Del322–325, β 1 Ser49, β 1 Arg389 and the risk for heart failure in the Japanese population
Author(s) -
n Shinpei,
Okamoto Hiroshi,
Akino Masatoshi,
Matsui Yutaka,
Fujio Yasushi,
Yoshiyama Minoru,
Takemoto Yasuhiko,
Yoshikawa Junichi,
Azuma Junichi,
Kitabatake Akira
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02447.x
Subject(s) - bonferroni correction , genotype , heart failure , medicine , population , allele , allele frequency , dilated cardiomyopathy , cardiomyopathy , polymorphism (computer science) , restriction fragment length polymorphism , endocrinology , cardiology , genetics , biology , gene , statistics , mathematics , environmental health
Aims We investigated the correlation of adrenergic receptor polymorphisms, α 2c Del322–325, β 1 Ser49Gly and β 1 Arg389Gly, with the risk of heart failure in the Japanese population. Methods These polymorphisms were analysed by polymerase chain reaction‐restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group. Results There were no differences or any trends in the allele and genotype frequencies of the β 1 Ser49Gly and β 1 Arg389Gly polymorphisms. The allele frequency of the α 2c Del322–325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance ( P = 0.022 > 0.017, by Bonferroni correction). Conclusions In this population, the variants β 1 Ser49, β 1 Arg389, and α 2c Del322–325 do not appear to be risk factors for chronic heart failure due to DCM. The α 2c Del322–325 variant may in fact confer some protection.