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Modelling approaches to dose estimation in children
Author(s) -
Johnson Trevor N.
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02429.x
Subject(s) - dose , medicine , estimation , pediatrics , population , adverse effect , drug , intensive care medicine , pharmacology , environmental health , management , economics
Most of the drugs on the market are originally developed for adults and dosage selection is based on an optimal balance between clinical efficacy and safety. The aphorism ‘children are not small adults’ not only holds true for the selection of suitable drugs and dosages for use in children but also their susceptibility to adverse drug reactions [1]. Since children may not be subject to dose escalation studies similar to those carried out in the adult population, some initial estimation of dose in paediatrics should be obtained via extrapolation approaches. However, following such an exercise, well‐conducted PK‐PD or PK studies will still be needed to determine the most appropriate doses for neonates, infants, children and adolescents.