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Pharmacokinetic evidence for the induction of lopinavir metabolism by efavirenz
Author(s) -
Dailly Eric,
Allavena Clotilde,
Raffi François,
Jolliet Pascale
Publication year - 2005
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2005.02369.x
Subject(s) - lopinavir , efavirenz , ritonavir , reverse transcriptase inhibitor , lopinavir/ritonavir , pharmacokinetics , confidence interval , pharmacology , medicine , human immunodeficiency virus (hiv) , virology , viral load , antiretroviral therapy
Aims The influence of efavirenz on lopinavir pharmacokinetics was investigated using a population approach. Methods Forty‐five HIV patients treated with lopinavir/ritonavir plus efavirenz (A) and 24 patients treated with lopinavir/ritonavir plus nucleoside/nucleotide reverse transcriptase inhibitors (B) were studied. Results A relationship ( P < 0.01) was established between the elimination rate constant of lopinavir ( k 10 ) and treatment with efavirenz. Mean k 10 was higher in group A than in group B (0.3838 vs 0.2810 h −1 ) ( P < 0.001, 95% confidence interval for difference between means 0.1004, 0.1052). Conclusions These results suggest that lopinavir metabolism is induced by efavirenz.