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The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects
Author(s) -
Ziviani Luigi,
Da Ros Lucio,
Squassante Lisa,
Milleri Stefano,
Cugola Mauro,
Iavarone Laura E.
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.2001.bjcp119.x
Subject(s) - lacidipine , simvastatin , pharmacokinetics , crossover study , dihydropyridine , pharmacology , medicine , chemistry , antagonist , calcium , placebo , receptor , alternative medicine , pathology
Aims Lacidipine, a long acting 2, 4‐dihydropyridine calcium channel antagonist is frequently administered with cholesterol lowering agents, particularly in elderly populations. The effects of lacidipine on the pharmacokinetics of simvastatin were investigated, since they share the CYP3A4 pathway for metabolism. Methods The study was an open, randomised, two‐way crossover design, with at least 7 days washout. Eighteen healthy subjects received simvastatin, 40 mg once daily, alone and together with lacidipine, 4 mg once daily, for 8 days. The pharmacokinetics of simvastatin were studied on the eighth day. Analysis was made of total simvastatin acid concentrations (naive simvastatin acid plus that derived from alkaline hydrolysis of the lactone). Results Lacidipine increased the maximum concentration of simvastatin ( C max ) by approximately 70% ( P =0.016) and the area under the plasma concentration‐time curve AUC(0,24 h) by approximately 35% ( P =0.001). The mean C max and AUC(0,24 h) of simvastatin (95% confidence interval) when given alone were 8.76 (6.72–11.41) ng ml −1 and 60.36 (47.15–77.28) ng ml −1 h. During treatment with lacidipine they were, respectively, 14.89 (10.77–20.58) ng ml −1 and 80.96 (64.62–101.44) ng ml −1 h. No significant differences were observed in either time to peak concentration ( t max was 1.0 h for simvastatin alone and 1.5 h for the combination) or in the half‐life ( t 1/2,z was 8.5 h in both cases). The combination was safe and well tolerated. Conclusions The observed increased exposure to simvastatin 40 mg following coadministration of lacidipine is unlikely to be of clinical relevance.