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Lanreotide inhibits human jejunal secretion induced by prostaglandin El in healthy volunteers
Author(s) -
SOBHANI IRADJ,
RENÉ AKLI RAMDANI EMMANUEL,
BAYOD FAYSEL,
SABBAGH LUIS C.,
THOMAS FRANÇOIS,
MIG MICHEL
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1996.tb00167.x
Subject(s) - somatostatin , lanreotide , jejunum , medicine , endocrinology , ileum , saline , gastroenterology , basal (medicine) , prostaglandin , chemistry , hormone , insulin , growth hormone , acromegaly
1 Somatostatin inhibits hormonal secretions in the gastrointestinal tract. Somatostatin analogues are used in the treatment of VIPome‐related watery diarrhoea. In addition, more than 10% of patients with AIDS suffer from diarrhoea likely due to the increased intestinal secretion of water and ions. However, the direct effect of somatostatin on the flux of water and ions in the intestine has not been, so far, analyzed in vivo. The aim of the present study was to evaluate the effect of lanreotide, a somatostatin analogue, on the movements of water and ions in the jejunum in man. 2 Accordingly, 10 healthy volunteers (age 18–35 years, mean 27) and two patients with AIDS (26 and 33 years) suffering from water diarrhoea (> 800 ml day ‐1 ) underwent intestinal perfusion using a four lumen tube with proximal occluding balloon. The segment tested was 25 cm long. The jejunum was infused by an isotonic control saline solution containing polyethylene glycol (PEG) as non‐absorbable marker. Basal jejunal secretions were measured in all subjects. Prostaglandin E l (PGE 1 ) was administered intraluminally to stimulate jejunal secretion in healthy volunteers. The effect of intravenous lanreotide on the jejunal PGE 1 ‐induced secretions of water and electrolytes was analysed in healthy subjects and on the basal secretions in AIDS patients. Each period was analyzed on the basis of three (10 min) successive intestinal juice collections after 20–30 min equilibration time. The antisecretory effect of lanreotide was evaluated in each subject as the difference between fluxes compared to the control period. 3 In healthy volunteers, PGE 1 induced secretion of H 2 O, Na + , K + and C1 ‐ in the jejunum and lanreotide reduced significantly PGE 1 ‐induced response. In both AIDS patients basal fluxes of water and ions were reduced by lanreotide in a dose‐dependent manner. 4 Somatostatin can reduce stimulated‐jejunal secretion of ions and water in normal subjects and may improve water diarrhoea in AIDS patients.