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Effect of food on the comparative pharmacokinetics of modified‐release morphine tablet formulations, Oramorph SR and MST Continus
Author(s) -
A. J. MILLER,
SMITH K J.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1996.tb00124.x
Subject(s) - bioequivalence , bioavailability , pharmacokinetics , medicine , absorption (acoustics) , morphine , absorption rate , pharmacology , equivalence (formal languages) , chromatography , anesthesia , mathematics , chemistry , materials science , composite material , discrete mathematics
In their recent paper Drake et al. [1] have expressed the opinion that Oramorph SR tablets and MST CONTINUS tablets are‘readily interchangeable’in patients receiving either product for pain control. This is based on the equivalence of the extent of availability of morphine from the two preparations. However, guidelines on bioequivalence issued by the authorities of the European Community define bioavailability in terms of both the rate and extent of absorption [2]. The authors appear to have chosen to disregard the statistically significant difference in C max between the preparations, the mean C max associated with the Oramorph SR Tablet (13.9 ng ml ‐1 ) was 30% higher than that associated with the MST CONTINUS tablet (10.7 ng ml ‐1 ) which indicates that the rate of absorption from the two preparations was different. Therefore, we do not accept that the two products are interchangeable.