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Diltiazem does not always increase blood cyclosporin concentration
Author(s) -
JONES TERRY E.,
MORRIS RAYMOND G.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1996.tb00123.x
Subject(s) - diltiazem , itraconazole , pharmacokinetics , pharmacology , drug interaction , ciclosporin , drug , medicine , chemistry , calcium , chemotherapy , antifungal , dermatology
The pharmacokinetic interaction between the calcium channel blocking drug, diltiazem (DTZ), the antifungal agent itraconazole (ICZ) and the immunosuppressive drug cyclosporin (CsA) was studied in a patient with a single lung transplant. The CsA area under curve estimations demonstrated a significant increase when ICZ was co‐prescribed (5836 μg l ‐1 h vs 8159 μg l ‐1 h) but no increase when DTZ was co‐prescribed with CsA (5836 μg l ‐1 h vs 5069 μg l ‐1 h). Despite widespread use as a CsA‐sparing agent, DTZ does not always increase CsA concentrations.