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Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HC1 in man
Author(s) -
SAMBOL N. C.,
BROOKES L. G.,
CHIANG J.,
GOODMAN A. M.,
LIN E. T.,
LIU C. Y.,
BENET L. Z.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1996.tb00017.x
Subject(s) - bioavailability , bioequivalence , pharmacokinetics , dosage form , metformin , pharmacology , absorption (acoustics) , medicine , chemistry , materials science , insulin , composite material
The pharmacokinetics of four single‐dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.