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Determination of the minimum dose of lactose drug carrier that can be sensed during inhalation.
Author(s) -
Higham MA,
Sharara AM,
Magee RP,
Ind PW
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb05786.x
Subject(s) - lactose , inhalation , placebo , pharmacology , drug , medicine , anesthesia , respiratory system , chemistry , food science , pathology , alternative medicine
Lactose is commonly used as a carrier for inhaled drugs. Twenty healthy volunteers without respiratory symptoms inhaled seven different doses of lactose and a placebo (empty) dose through the four place Diskhaler device, in order to determine the lowest dose that could be reliably sensed. The minimum dose for which all subjects reported taste or feel sensations was 10 mg. This has implications regarding the amount of carrier used in future drug delivery systems.