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Effect of diadenosine phosphates on human umbilical vessels: novel platelet‐derived vasoconstrictors.
Author(s) -
Davies G.,
MacAllister RJ,
Bogle RG,
Vallance P.
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb05773.x
Subject(s) - theophylline , adenosine , platelet , in vitro , chemistry , adenosine diphosphate , umbilical artery , blood vessel , vasodilation , pharmacology , medicine , endocrinology , platelet aggregation , biochemistry , biology , pregnancy , fetus , genetics
The responses of human isolated umbilical artery to the novel platelet‐ derived mediators, diadenosine phosphates, P1,P5‐di(adenosine‐ 5′)pentaphosphate (AP5A) and P1,P6‐di(adenosine‐5′)hexaphosphate (AP6A) were studied in vitro. AP5A (1 nM‐300 microM; n = 7) and AP6A (1 nM‐30 microM; n = 5) produced transient concentration‐dependent contractions. Responses to AP5A were unaffected by co‐incubation with indomethacin (10 microM; n = 4), NGmonomethyl‐L‐arginine (L‐NMMA; 300 microM; n = 4) and theophylline (1 microM; n = 5). These results demonstrate that diadenosine phosphates have constrictor effects on human blood vessels in vitro and are consistent with a role for these platelet‐derived mediators in the regulation of blood vessel tone.