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Lack of effect of pantoprazole on the pharmacodynamics and pharmacokinetics of warfarin [see comments]
Author(s) -
Duursema L.,
Muller FO,
Schall R.,
Middle MV,
Hundt HK,
Groenewoud G.,
Steinijans VW,
Bliesath H.
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb05732.x
Subject(s) - pantoprazole , pharmacokinetics , warfarin , pharmacodynamics , placebo , medicine , warfarin sodium , prothrombin time , cmax , crossover study , pharmacology , confidence interval , omeprazole , atrial fibrillation , alternative medicine , pathology
Twenty‐six healthy males took part in this double‐blind, randomised, placebo‐controlled, two‐period, cross‐over study. Pantoprazole (40 mg) (test) or placebo (reference) were administered once daily, for 8 days, with a 3 week washout period. A single oral dose of 25 mg warfarin sodium was co‐administered with pantoprazole or placebo on Day 2 of each treatment period. The 90% confidence intervals for the 'test/reference' mean ratios of the excess AUC(0.168 h) of prothrombin time and AUC(0.168 h) of factor VII, and of Cmax, AUC and t1/2 of both R‐ and S‐warfarin fell within the equivalence range of 80% to 125%. These results suggest that pantoprazole does not alter the pharmacokinetics or pharmacodynamics of warfarin.