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Influence of arterio‐venous haemofiltration on teicoplanin elimination.
Author(s) -
HillaireBuys D,
Peyriere H,
Lobjoie E,
Bres J,
Ossart M,
Despaux E
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04543.x
Subject(s) - teicoplanin , pharmacokinetics , medicine , anesthesia , plasma concentration , gastroenterology , pharmacology , urology , vancomycin , biology , bacteria , genetics , staphylococcus aureus
The pharmacokinetics of teicoplanin infused for 30 min at a dose of 6 mg kg‐1 was studied in 11 infected patients under continuous arterio‐ venous haemofiltration (CAVH). Serum teicoplanin levels were assayed by h.p.l.c. over 24 h. After 0.5 h, i.e. at the end of the infusion, the mean plasma concentration was 49.6 +/‐ 15.1 mg l‐1. At the last sampling time (24 h), the mean concentration was 2.6 +/‐ 1.0 mg l‐1. The concentration of teicoplanin was determined in the haemofiltrates. The percentage of the administered dose recovered in the haemofiltrate was low: less than 1% for seven patients, between 1.8 and 3.7% for three patients and 7% for one patient. CAVH patients should be given teicoplanin using the same dosage regimens as previously described for patients with renal impairment.