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Absorption of clonazepam after intranasal and buccal administration.
Author(s) -
ScholsHendriks MW,
Lohman JJ,
Janknegt R,
Korten JJ,
Merkus FW,
Hooymans PM
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04476.x
Subject(s) - clonazepam , nasal administration , buccal administration , cmax , medicine , oral administration , absorption (acoustics) , pharmacology , pharmacokinetics , anesthesia , physics , acoustics
Serum concentrations of clonazepam after intranasal, buccal and intravenous administration were compared in a cross‐over study in seven healthy male volunteers. Each subject received a 1.0 mg dose of clonazepam intranasally and buccally and 0.5 mg intravenously. A Cmax of 6.3 +/‐ 1.0 ng ml‐1 (mean; +/‐ s.d.) was measured 17.5 min (median) (range 15‐20 min) after intranasal administration. A second peak (4.6 +/‐ 1.3 ng ml‐1) caused by oral absorption was seen after 1.7 h (range 0.7‐3.0 h). After buccal administration a Cmax of 6.0 +/‐ 3.0 ng ml‐1 was measured after 50 min (range 30‐90 min) with a second peak of 6.5 +/‐ 2.5 ng ml‐1 after 3.0 h (range 2.0‐4.0 h). Two minutes after i.v. injection of 0.5 mg clonazepam the serum concentration was 27 +/‐ 18 ng ml‐1. It is concluded that intranasal clonazepam is an alternative to buccal administration. However, the Cmax of clonazepam after intranasal administration is not high enough to recommend the intranasal route as an alternative to intravenous injection.