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Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia.
Author(s) -
Cutler N,
Sramek J,
Veroff A,
Block G,
Stauffer L,
Lines C
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04458.x
Subject(s) - pravastatin , simvastatin , placebo , medicine , crossover study , double blind , pharmacology , cholesterol , anesthesia , alternative medicine , pathology
The effects of equi‐efficacious doses of the cholesterol‐lowering drugs simvastatin (20 mg day‐1) and pravastatin (40 mg day‐1) on tests of cognitive function were investigated in a double‐blind, placebo‐ controlled, 2‐period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.