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Patient‐controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan.
Author(s) -
Persson K,
Sjostrom S,
Sigurdardottir I,
Molnar V,
HammarlundUdenaes M,
Rane A
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04428.x
Subject(s) - codeine , dextromethorphan , medicine , anesthesia , opiate , pharmacology , morphine , receptor
Postoperative pain relief with codeine was evaluated in 11 women undergoing hysterectomy. Patient‐controlled analgesia (PCA) was used to administer codeine. After the study the patients were phenotyped with respect to the O‐demethylation of dextromethorphan (cytochrome P4502D6 polymorphism). Ten were extensive metabolisers and one a poor metaboliser. There was a nine‐fold variation in the minimum plasma concentration of codeine consistent with pain relief (40‐350 ng ml‐1). Two patients did not experience any effect of codeine, one of whom was a poor metaboliser of dextromethorphan, confirmed by genotyping. In the other nine patients the effective dose of codeine varied from 4.8‐25.3 mg h‐1.