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Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects.
Author(s) -
Wong LT,
Sitar DS,
Aoki FY
Publication year - 1995
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1995.tb04414.x
Subject(s) - amantadine , medicine , disposition , body mass index , volume of distribution , renal function , pharmacokinetics , endocrinology , pharmacology , psychology , social psychology
Amantadine HCl (3 mg kg‐1) was administered orally to 20 young healthy adults. Its apparent volume of distribution (V2/F) was higher in smokers than nonsmokers, 6.05 +/‐ 0.86 vs 4.87 +/‐ 0.85 l kg‐1; (mean +/‐ s.d., 10/group, P < 0.011), and no gender‐associated effect was observed. Renal clearance did not vary with time‐interval, but urinary recovery at 48 h was higher in men than in women (60.2 +/‐ 7.5% vs 47.0 +/‐ 15.0%, P < 0.032). Males had higher renal clearances than females when normalised for body mass index (BMI, 0.492 +/‐ 0.284 vs 0.248 +/‐ 0.137 l‐1 BMI h‐1, (10/group, P < 0.032)). On combining data from a previous study, the weight normalised renal clearance was also higher in men than in women, 0.160 +/‐ 0.075 vs 0.102 +/‐ 0.053 l kg‐1 h‐1 (19/group, P < 0.01). Chronic tobacco smoking did not alter the plasma or renal amantadine clearance. We conclude that gender and tobacco smoking are independent variables effecting amantadine disposition.