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Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test.
Author(s) -
Parker AC,
Preston T,
Heaf D,
Kitteringham NR,
Choonara I
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04399.x
Subject(s) - caffeine , cyp1a2 , cystic fibrosis , ciprofloxacin , breath test , pharmacology , medicine , chemistry , cytochrome p450 , metabolism , antibiotics , biochemistry , helicobacter pylori
The caffeine breath test was carried out in six children with cystic fibrosis, before and during a course of ciprofloxacin. There was a significant decrease in the 2 h cumulative labelled CO2 exhaled during ciprofloxacin treatment, mean difference (s.d.) ‐5.2(3.3)%, P < 0.02. The results suggest an inhibition of 3‐N‐demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin. Ciprofloxacin may cause significant drug interactions in children with cystic fibrosis. The caffeine breath test can be used to study drug interactions involving CYP1A2 in children.