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Stereoselective disposition of ibuprofen enantiomers in infants.
Author(s) -
Rey E,
ParienteKhayat A,
Gouyet L,
VauzelleKervroedan F,
Pons G,
D'Athis P,
Dubois MC,
Murat I,
Lassale C,
Goehrs M
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04369.x
Subject(s) - ibuprofen , enantiomer , pharmacokinetics , stereoselectivity , oral administration , pharmacology , chemistry , plasma concentration , oral dose , medicine , stereochemistry , organic chemistry , catalysis
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/‐ 0.3 mg kg‐1 dose of the racemate in 11 infants. Mean (+/‐ s.d.) half‐lives were 1.6 +/‐ 0.5 h for S(+) and 1.5 +/‐ 0.5 h for R(‐) and mean (+/‐ s.d.) AUC values were 31.5 +/‐ 14.3 mg l‐1 h for S(+) and 36.6 +/‐ 13.8 mg l‐1 h for R(‐). Since plasma concentrations of the active S(+)‐isomer were lower than those reported in adults, a higher dosage might be required in infants.