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Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients.
Author(s) -
Scholz J,
Bause H,
Schulz M,
Klotz U,
Krishna DR,
Pohl S,
Schulte am Esch J
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04368.x
Subject(s) - sufentanil , anesthesia , medicine , pharmacokinetics , intracranial pressure , bolus (digestion) , cerebral perfusion pressure , midazolam , intravenous bolus , blood pressure , mean arterial pressure , perfusion , surgery , cerebral blood flow , sedation , heart rate
Ten patients with head trauma received an intravenous bolus of sufentanil (2 micrograms kg‐1) followed at 30 min by infusion of sufentanil (median 150 micrograms h‐1) and midazolam (median 9.0 mg h‐ 1) over 48 h. Median (range) values of pharmacokinetic parameters for sufentanil were: t1/2,z = 16 (7‐49) h; CL = 1215 (519‐2550) ml min‐1; CLR = 7 (2‐38) ml min‐1; Vss = 10.0 (6.8‐24.2) 1 kg‐1. Decreases in intracranial pressure (ICP) (from 16.1 +/‐ 1.7 to 10.8 +/‐ 1.3 mm Hg; P < 0.05) and mean arterial blood pressure (MAP) (from 85.5 +/‐ 3.9 to 80.2 +/‐ 4.9 mm Hg; P < 0.05) were observed within 15 min of the bolus injection of sufentanil and remained unchanged thereafter. Thus, cerebral perfusion pressure (CPP = MAP‐ICP) was stable.