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Anti‐emetic effect of high‐dose metoclopramide vs alizapride—a randomised crossover study.
Author(s) -
Seng KT,
Tiong CE,
Hiang TC
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04355.x
Subject(s) - metoclopramide , crossover study , medicine , anesthesia , antiemetic , pharmacology , vomiting , alternative medicine , pathology , placebo
A randomised double‐blind crossover study was undertaken to compare the anti‐emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg‐1 day‐1) or alizapride (5 mg kg‐1 day‐ 1). Anti‐emetic responses in terms of control of vomiting episodes were similar in both regimens (59%). However, patients showed a statistically significant preference for high dose metoclopramide (P = 0.02). Side effects of both regimens were minimal. We conclude that alizapride is not superior to high dose metoclopramide in controlling cisplatin induced vomiting.