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Colchicine concentration in leukocytes of patients with familial Mediterranean fever.
Author(s) -
Chappey O,
Niel E,
Dervichian M,
Wautier JL,
Scherrmann JM,
Cattan D
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04328.x
Subject(s) - colchicine , familial mediterranean fever , peripheral blood mononuclear cell , radioimmunoassay , medicine , granulocyte , endocrinology , chemistry , immunology , pharmacology , biochemistry , in vitro , disease
Free and total plasma, granulocyte and mononuclear cell colchicine concentrations were measured by radioimmunoassay in 30 patients with familial Mediterranean fever treated with colchicine 0.5 to 2 mg day‐1. Colchicine concentrations showed a large intersubject variability in plasma (0.13‐1.75 ng ml‐1), granulocytes (4 to 64 ng/10(9) cells), and mononuclear cells (11.4 to 57.6 ng/10(9) cells). Whereas unbound and total plasma colchicine concentrations were well correlated, no correlation was found between total or free plasma and granulocyte or mononuclear cell colchicine concentrations and dose of administered colchicine. In contrast, total or free plasma and granulocyte or mononuclear cell colchicine concentrations were correlated using a hyperbolic function indicating saturable colchicine distribution in both leukocyte populations.