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Absorption of ipsapirone along the human gastrointestinal tract.
Author(s) -
Fuhr U,
Staib AH,
Harder S,
Becker K,
Liermann D,
Schollnhammer G,
Roed IS
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04327.x
Subject(s) - gastrointestinal tract , bioavailability , rectum , capsule , medicine , drug , absorption (acoustics) , pharmacokinetics , pharmacology , gastroenterology , biology , botany , physics , acoustics
Isapirone‐HCl (5 mg) was administered orally, rectally and locally, by a remote control drug delivery device (HF‐capsule) into different segments of the gastrointestinal tract, to four young healthy male adults. The relative systemic bioavailability of the drug from the colon and rectum was 2‐3‐fold greater than that from the upper gastrointestinal tract. This supports a rationale for a prolonged‐ release formulation.