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The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients.
Author(s) -
Yeates RA,
Ruhnke M,
Pfaff G,
Hartmann A,
Trautmann M,
Sarnow E
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04325.x
Subject(s) - pharmacokinetics , fluconazole , medicine , renal function , creatinine , metabolic clearance rate , clearance , human immunodeficiency virus (hiv) , gastroenterology , urology , anesthesia , antifungal , immunology , dermatology
The pharmacokinetics of fluconazole after a single 100 mg i.v. dose were studied in 10 healthy subjects (5 M; 5 F) and 10 HIV‐positive patients (8 M; 2 F). The mean value of plasma clearance was 25% lower in the patient groups (17 +/‐ 6 (s.d.) vs 23 +/‐ 4 ml min‐1; 95% CI of difference ‐11 to ‐0.7; P < 0.05). This difference may have been related to slightly reduced kidney function in the patient group (mean creatinine clearance ‐18%) but is unlikely to be clinically significant. Therefore, no adjustment of the dose of intravenously administered fluconazole appears to be necessary in AIDS patients without clinical signs of enteropathy.