Premium
Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children [see comments]
Author(s) -
Olkkola KT,
Hamunen K,
Seppala T,
Maunuksela EL
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04324.x
Subject(s) - anesthesia , oxycodone , heart rate , medicine , pharmacokinetics , volume of distribution , blood pressure , analgesic , tidal volume , respiratory system , pharmacology , opioid , receptor
1. Oxycodone hydrochloride (0.1 mg kg‐1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end‐tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean (+/‐ s.d.) values of drug clearance and volume of distribution (Vss) were 15.2 +/‐ 4.2 ml min‐1 kg‐1 and 2.1 +/‐ 0.8 l kg‐1. Maximum mean end‐tidal carbon dioxide concentration and minimum mean ventilatory rate occurred 8 min after administration of oxycodone but the minimum mean peripheral arteriolar oxygen saturation occurred at 4 min. 3. Oxycodone (0.1 mg kg‐1) appears to cause greater ventilatory depression than comparable analgesic doses of other opioids.