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The efficacy of locally applied morphine in post‐operative pain after bilateral third molar surgery.
Author(s) -
Moore UJ,
Seymour RA,
Gilroy J,
Rawlins MD
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04267.x
Subject(s) - analgesic , morphine , molar , medicine , placebo , anesthesia , surgery , clinical efficacy , dentistry , alternative medicine , pathology
1. Recent evidence has hinted at a peripheral site of action of morphine analgesic efficacy. 2. Previous studies by the same authors have developed a model for testing local analgesic efficacy by placing drugs into tooth sockets after third molar surgery. 3. The present studies test the hypothesis of local morphine activity at two dosage concentrations, 100 ng ml‐1 and 100 micrograms ml‐1 after third molar surgery. 4. No significant analgesic efficacy was found at either dose when compared with placebo.