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An assessment of lacidipine and atenolol in mild to moderate hypertension.
Author(s) -
Lyons D,
Fowler G,
Webster J,
Hall ST,
Petrie JC
Publication year - 1994
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1994.tb04237.x
Subject(s) - lacidipine , atenolol , blood pressure , medicine , heart rate , crossover study , placebo , anesthesia , antagonist , cardiology , receptor , alternative medicine , pathology
1. The aim of this randomised, double‐blind four way crossover study was to assess the interaction between the new calcium antagonist, lacidipine and atenolol, in patients with mild to moderate hypertension. 2. Sitting blood pressure at 4 h post‐dosing with lacidipine (4 mg) and atenolol (100 mg) alone was significantly lower compared with placebo (137/89 +/‐ 3/3 mmHg; 142/89 +/‐ 5/3 mmHg; and 154/98 +/‐ 5/3 mmHg respectively; P < 0.001). Co‐administration of both drugs produced a significant additive effect compared with atenolol and lacidipine alone (124/80 +/‐ 4/2 mmHg; P < 0.002). 3. Heart rate on treatment with lacidipine alone was significantly greater at 4 h compared with placebo (86 +/‐ 1 beats min‐1 and 74 +/‐ 2 beats min‐1 respectively; P < 0.001). When both drugs were used in combination, there was a significant decrease in pulse rate compared with lacidipine alone (58 +/‐ 1 beats min‐1 and 86 +/‐ 1 beats min‐1 respectively; P < 0.001). 4. Home blood pressure recordings confirmed the statistically significant reduction in blood pressure on co‐dosing (120/82 +/‐ 10/2 mmHg) compared with lacidipine (140/92 +/‐ 5/3 mmHg) and atenolol (146/90 +/‐ 6/3 mmHg) given alone (P < 0.05). 5. Lacidipine alone produced a significant exercise tachycardia compared with atenolol alone and the atenolol/lacidipine combination (97 +/‐ 8 beats min‐1; 65 +/‐ 4 beats min‐1 and 75 +/‐ 7 beats min‐1 respectively; P < 0.001). Exercise tolerance was not adversely affected by the co‐administration of both lacidipine and atenolol.