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The basis of the histamine assay in human skin: II. Wheal formation.
Author(s) -
Carey C.,
Clark M.,
LopezGil JA,
Vere DW
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb05889.x
Subject(s) - histamine , isotonic saline , dermis , saline , chemistry , medicine , endocrinology , anatomy
1. Subepidermal injection of histamine solutions in isotonic saline in four subjects evoked whealing after a mean delay of 2.6 min, this estimate being derived by regression modelling. 2. Wheal growth was better modelled by the logarithm of time than by time, suggesting that wheal size depends upon assisted diffusion of histamine in the dermis. 3. Wheal growth was piecemeal, not continuous, consistent with the successive involvement of neighbouring vascular territories. 4. Wheal growth was completed by 9 min after injection.