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CNS‐related performance and haemodynamics of metoprolol‐Oros and propranolol after single and 3 days dosing in healthy volunteers.
Author(s) -
Steveninck AL,
Pieters MS,
Schoemaker HC,
Breimer DD,
Cohen AF
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb05676.x
Subject(s) - metoprolol , propranolol , heart rate , blood pressure , medicine , hemodynamics , anesthesia , crossover study , temazepam , placebo , alternative medicine , receptor , pathology , benzodiazepine
1. The effects of metoprolol‐Oros 14/190 once daily, propranolol 80 mg twice daily and temazepam 10 mg once daily on central nervous system (CNS) related performance and haemodynamic variables were evaluated in a double‐blind, randomized, placebo controlled, crossover study in 12 healthy volunteers. Drugs were administered for 3 consecutive days except for temazepam, which was administered on days 1 and 3 only. Treatment effects were evaluated at 0, 2, 5 and 8 h on days 1 and 3. 2. Neither beta‐adrenoceptor blocker had significant effects in a battery of tests after single or 3 days dosing. Temazepam caused a decrease in saccadic peak velocity of 37.4 degrees s‐1 (95% CI: 6.0, 68.9) at 2 h and an increase of auditory reaction times of 11.5 ms (0.2, 22.8) at 8 h on day 1. No significant effects of temazepam were detected on day 3. 3. Both beta‐adrenoceptor blockers reduced exercise heart rate. Peak effects were measured at 2 h 40 min after propranolol but not metoprolol‐Oros (difference, day 1:20 (11, 29) beats min‐1, day 3:13 (8, 19) beats min‐1). Both beta‐adrenoceptor blockers significantly reduced baseline exercise heart rate on day 3. Compared with day 1, metoprolol‐Oros caused larger reductions of exercise heart rate at all times on day 3. 4. Metoprolol‐Oros and propranolol caused similar reductions of systolic‐ and diastolic blood pressure on days 1 and 3. Temazepam caused a small reduction in diastolic blood pressure at 5 h 40 min on day 1 but was otherwise devoid of haemodynamic effects.(ABSTRACT TRUNCATED AT 250 WORDS)