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Paracetamol elimination in patients with non‐insulin dependent diabetes mellitus.
Author(s) -
Kamali F.,
Thomas SH,
Ferner RE
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb05672.x
Subject(s) - diabetes mellitus , medicine , insulin , pharmacology , endocrinology
The pharmacokinetics and metabolism of an intravenous dose (500 mg) of paracetamol were studied in a group of non‐insulin dependent diabetic patients (n = 10) and in a group of healthy control subjects (n = 9). Paracetamol clearance, half‐life and the partial clearance to paracetamol glucuronide were not significantly different, but the partial clearance to paracetamol sulphate was significantly reduced (62 +/‐ 18 vs 86 +/‐ 17 ml h‐1 kg‐1 (mean +/‐ s.d.)) and the renal clearance of paracetamol was significantly increased (56 +/‐ 20 vs 22 +/‐ 6 ml h‐1 kg‐1 (mean +/‐ s.d.)) in the non‐insulin dependent diabetic patients, compared with the control group.