Premium
Individual theophylline dosing based on bioelectrical impedance analysis.
Author(s) -
Sidhu JS,
Triggs EJ,
Charles BG,
Smithurst BA
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb04198.x
Subject(s) - theophylline , bioelectrical impedance analysis , medicine , body weight , dosing , anesthesia , chemistry , body mass index
The role of bioelectrical impedance (BI) analysis in determining slow‐ release theophylline dosage was evaluated in fifteen healthy subjects given a standard 200 mg dose. Reactance and l/resistance were identified as the most significant predictors of pre‐dose, steady‐state theophylline concentrations (Css, pre). Compared with doses based on body weight (8.8 mg kg‐1 day‐1), theophylline doses determined by BI analysis (9.6 +/‐ 2.4 mg kg‐1 day‐1) resulted in less biased (mean prediction error = 0.6 vs 1.4) though slightly less precise (mean squared error = 7.1 vs 6.3) Css, pre values. These differences were statistically insignificant (P > 0.05).