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Frusemide causes acute increases in lipid concentrations
Author(s) -
CAMPBELL NORMAN R. C.,
WICKERT WAYNE A.,
SHUMAK STEVEN L.
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb00423.x
Subject(s) - ingestion , furosemide , placebo , medicine , diuretic , lipid profile , oral administration , body weight , pharmacology , endocrinology , cholesterol , pathology , alternative medicine
In a randomized double‐blind placebo controlled parallel study involving fourteen healthy male volunteers, we examined whether the acute reduction in vascular volume associated with frusemide ingestion would haemoconcentrate lipid particles. Three hours after a single 40 mg oral dose of frusemide, there were 9.6–14.4% increases in lipids and lipoproteins which were highly correlated to changes in body weight. Until further studies determine the extent of haemoconcentration in patients being treated long term with frusemide, we recommend that blood be drawn for lipid analysis prior to frusemide ingestion.