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Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity
Author(s) -
BACHMANN K. A.,
SULLIVAN T. J.,
JAUREGUI L.,
REESE J. H.,
MILLER K.,
LEVINE L.
Publication year - 1993
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1993.tb00382.x
Subject(s) - phenytoin , omeprazole , disposition , pharmacology , anticonvulsant , pharmacokinetics , drug interaction , chemistry , medicine , epilepsy , psychology , social psychology , psychiatry
The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg −1 p.o. single dose) were studied in 18 healthy, young adult males. Total and unbound plasma concentrations of phenytoin were measured for 48 h after each dose of phenytoin. Neither treatment altered the disposition kinetics of phenytoin, the hydroxylation of which is mediated specifically by cytochromes P450 of the 2C subfamily.