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The low‐chloride cough response is not inhibited by a single, high dose of aspirin.
Author(s) -
Stone RA,
Barnes PJ,
Fuller RW
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb05645.x
Subject(s) - aspirin , pharmacology , chloride , airway , medicine , prostaglandin , anesthesia , drug , chemistry , organic chemistry
The effect of a single, high dose of aspirin has been assessed against low chloride cough challenge. The drug does not affect the cough response, suggesting that airway prostaglandin generation is not responsible for the tussive activity of low chloride solution.