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Diffusion of cloxacillin into synovial tissue.
Author(s) -
Mattie H,
Marie S,
Slaghuis G,
Rozing PM,
Strijen E
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04138.x
Subject(s) - cloxacillin , pharmacokinetics , chemistry , tissue distribution , synovial fluid , distribution (mathematics) , subcutaneous tissue , periprosthetic , antibiotics , medicine , surgery , arthroplasty , pathology , osteoarthritis , penicillin , biochemistry , alternative medicine , mathematics , mathematical analysis
After a 30 min i.v. infusion of 1 g cloxacillin, the concentrations of this antibiotic were measured in plasma and synovial tissue samples from 11 patients undergoing total hip replacement. Assuming passive distribution between plasma and tissue the rate constants of distribution were estimated. The mean half‐life of distribution was 22 min. The concentration of free drug in synovial tissue was estimated to be 77% of the total tissue concentration. The maximum tissue drug concentration after an i.v. bolus dose is predicted to occur at about 37 min.